HSPA 12B promotes functional recovery after ischaemic stroke through an eNOS ‐dependent mechanism
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چکیده
منابع مشابه
HSPA12B promotes functional recovery after ischaemic stroke through an eNOS‐dependent mechanism
Stroke is the leading cause of disability worldwide. HSPA12B, a heat-shock protein recently identified expression specifically in endothelial cells, is able to promote angiogenesis. Here, we have investigated its effects on functional recovery at chronic phase of ischaemic stroke. Ischaemic stroke was induced by 60 min. of middle cerebral artery occlusion in transgenic mice with overexpression ...
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AIMS HSPA12B is a newly discovered and endothelial-cell-specifically expressed heat shock protein. We have reported recently that overexpression of HSPA12B increased endothelial nitric oxide synthase (eNOS) expression in mouse cardiac tissues during endotoxemia. Endothelial NOS has been shown to protect heart from ischaemic injury. We hypothesized that overexpression of HSPA12B will attenuate c...
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ژورنال
عنوان ژورنال: Journal of Cellular and Molecular Medicine
سال: 2018
ISSN: 1582-1838,1582-4934
DOI: 10.1111/jcmm.13507